Effectiveness of using platelet concentrate and blood clot in regenerative endodontic treatment: A systematic review and meta-analysis

Hari Krishnan Venkatakrishnan¹ image, Nihal Rajendra Kothari2 image, Srinath Krishnappa3 image

 

Highlights

The primary objective of the review was to ascertain the optimal scaffold for pulp regeneration based on an extensive examination of existing literature.

Platelet concentrates demonstrated notable efficacy in comparison to blood clots; however, the meta-analysis failed to establish statistical significance.

Given the transformative potential of these scaffolds in the realm of regeneration, there is a pressing need for studies with extended longitudinal observation periods.

Abstract

This review sought to compare the efficacy of blood clots, Platelet-rich Plasma (PRP), and Platelet-rich Fibrin (PRF) in regenerative endodontic procedures. A systematic electronic search was conducted across major databases. The primary endpoints encompassed radiographic evidence of periapical healing, sustained root development, and root dentin thickening in studies with a follow-up duration of at least 6 months. Fourteen randomized controlled trials were encompassed within the analysis. Among these, five instances were documented as treatment failures, while the remaining studies exhibited complete resolution of symptoms across all three intervention groups. Meta-analysis was performed using failure rate data extracted from the selected studies, revealing no statistically significant discrepancies between the groups. Despite inherent limitations, the findings suggest comparable outcomes between the use of platelet concentrates as scaffolds and blood clots in the specified clinical context.

Keywords: Platelet-Rich Plasma; Platelet-Rich Fibrin; Regenerative Endodontics

Author Affiliations

  1. Postgraduate Student, Department of Pediatric and Preventive Dentistry, Government Dental College and Research Institute, India (Correspondence:harikrishnanve@gmail.com)
  2. MDS, Department of Pediatric Dentistry, Pacific Dental College & Hospital, India
  3. Professor, Department of Pediatric and Preventive Dentistry, Government Dental College and Research Institute, India
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Article Info

Contemp Pediatr Dent 2024:5(1):1-14

Received: 15 November 2023

Accepted: 28 February 2024

Online First: 14 March 2024

DOI: 10.51463/cpd.2023.186

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					Hari Krishnan Venkatakrishnan, Nihal Rajendra Kothari, Srinath Krishnappa. Effectiveness of using platelet concentrate and blood clot in regenerative endodontic treatment: A systematic review and meta-analysis. Contemp Pediatr Dent 2024:5(1):1-14.

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