Comparison of two vital pulp therapies in β-Thalassemic children

Original Research

Contemp Pediatr Dent 2020:1(1):33-41

Comparison of two vital pulp therapies in β-Thalassemic children

OrcidLeila Mounir El. Gibaly1 ✉, OrcidMohamed Zayed Radwan2, OrcidAmr Mahmoud Abdel-Aziz3, OrcidGhada Yousef El.Kamah4


1. Research assistant in Oro-dental Genetics Department, Human Genetics and Genome Research Division, National Research center, El Buhouth street (formerly named Tahrir street), Ad Doqi, Dokki, Cairo, 12622. ( Correspondence:

2. Lecturer in Pediatric Dentistry and Dental Public Health Department, Ain Shams University, Cairo, Egypt, 11566

3. Professor in Pediatric Dentistry and Dental Public Health Department,Faculty of Dentistry, Ain Shams University Cairo, Egypt, 11566

4. Professor of Clinical Genetics and Coordinator of Hereditary Blood Disorders and Genodermatosis Clinics and Research Division, National Research center, 33 El Buhouth street (formerly named Tahrir street), Ad Doqi, Dokki, Cairo, Egypt


This study compared two vital pulp therapy techniques: mineral trioxide aggregate pulpotomy and indirect pulp capping in children with β-thalassemia major who cannot withstand the stress of the dental chair for long.

Both techniques had high success rates with no statistically significant difference between them. However, patient satisfaction was higher with indirect pulp capping than pulpotomy.

Both types of vital pulp therapies may be applied to β-thalassemic children with higher success rates.


Aim: Beta-thalassemia (β-thalassemia) major is one of the most common inherited genetic blood disorders and is characterized by many systemic manifestations and skeletal problems. Children with β-thalassemia have a high caries index and must receive proper dental treatment to achieve better oral health. The aim of study is to compare two types of vital pulp therapies in children with β-thalassemia major. Methods: Sixty-five children with β-thalassemia major having carious primary molars were selected from Ain Shams University and the Hereditary Blood Disorders Clinic at the National Research Centre to be treated at Pediatric Dentistry, Department, Faculty of Dentisrtry, Ain Shams University . Patients received one of both types of vital pulp therapies: mineral trioxide aggregate (MTA) pulpotomy and indirect pulp capping. The children were divided into two groups as follow: Group I (n=30) received MTA pulpotomy and Group II (n=35) received indirect pulp capping using high viscosity glass ionomer cement. Clinical and radiographic follow-ups were done at the baseline, six months, and after one year. Patient preferences for types of vital pulp therapies were evaluated at the end of treatment. Comparison of the groups with qualitative data was done using Chi-square test. Comparison of the groups with quantitative data and a parametric distribution was done using an independent t-test at significance level 0.05. Results:  The findings revealed success rates of 90% in Group I and 100% in Group II. There was 10% clinical and radiographic failure in Group I and 0% in Group II but the difference between the two groups when compared to each other was statistically not significant (p= 0.055). Conclusions:  Both types of vital pulp therapies showed high success rates in children with β-thalassemia major and thus can be used safely in these patients. However, minimally invasive types of dental treatment may be preferred in children with β-thalassemia major as indirect pulp capping for being less invasive and requires less effort, fatigue and time.

Keywords: Calcium Silicate; Dental Pulp Capping; Pulpotomy; Thalassemia

Copyright © 2020 Contemporary Pediatric Dentistry


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03 October 2020


04 December 2020

Online First:

15 December 2020